ORCID ID 0000-0003-0765-2127
Current Position: Giorgia Oliviero PhD, is associate professor of Organic Chemistry since 2016 at Department of Molecular medicine and medical biotechnologies.
Research activity and interest: Currently, Prof. Oliviero’s research activity is mainly focused on the synthesis of quadruplex-forming oligonucleotides and peptide nucleic acids to be used as new drugs or as innovative diagnostic tools. DNA quadruplexes are non-canonical secondary structures of DNA and RNA that receive much attention for many reasons. First of all, they represent potential targets for drugs, being present in biologically relevant regions of DNA, such as telomeres, switch regions of immunoglobulins and many gene promoters. Furthermore, DNA quadruplexes have been found in oligonucleotides capable to bind with high specificity and affinity to selected proteins involved in human diseases (DNA aptamers). In this frame, Prof. Oliviero has recently achieved interesting results, such as the design and the synthesis of a novel class of anti-HIV aptamers and new analogues of thrombin-binding aptamer with improved anticoagulant activity. As concerning the development of innovative diagnostic tools, Dr Oliviero has recently achieved promising results in the direct synthesis of oligonucleotide strands on porous silica supports (PSi). It is well known that PSi supports are suitable for implementation in label-free molecular recognition techniques thanks to their peculiar optical features. Professor Giorgia Oliviero is the author of more than 100 papers published in international peer-reviewed journals.
Ongoing Research funding’s projects
PRIN 2017: Mussel-inspired functional biopolymers for underwater adhesion, surface/interface derivatization and nanostructure/composite self-assembly (MUSSEL) 2017YJMPZN
PO FESR 2014-2020 – REGIONE CAMPANIA “Progetti Trasferimento Tecnologico e di prima
Industrializzazione per le imprese innovative ad alto potenziale per la lotta alle patologie
oncologiche – Campania Terra del Buono” -Biochip per la diagnosi rapida ed il follow-up della
leucemia linfatica cronica nella popolazione in territorio a rischio. Pproject onc3-003145(DG10 staff 93 n°354, 05/06/2017)