29th June
Sunday
17:00-19:00 Registration at Sala Raffaello
19:30 Welcome Dinner & Networking at Hotel Restaurant
21:00 After Dinner: Drinks and Networking together with Pappardelle ai Funky group at Sala Raffaello
30th June
Monday
Chair: Valeria Costantino, Giorgia Oliviero, Luigi Milella, Roberta Teta and Germana Esposito
9:00 Opening
9:15 – 9:45 Vitor Vasconcelos (ISSNP External Board Member)Opening Lecture & discussion
University of Porto and CIIMAR, Porto (PORTUGAL)
Title: Blue Natural Products & Sustainable Research
Session I: Genome mining and Natural Product Discovery: from genes to molecules
Lecture and Workshop
10:00 – 11:30 Gerardo Della Sala
Stazione Zoologica Anton Dohrn, Naples (ITALY)
Gain insight into how genomics has given a new pulse to natural product discovery in recent years. The first part of the session will introduce the biosynthesis of polyketides (PK) and non-ribosomal peptides (NRP). The second part aims to provide the tools to unlock the PK and NRP biosynthetic genes and predict the chemical structures of the encoded metabolites through the analysis of biosynthetic gene clusters using the Antismash platform. The practical session will allow one to get familiar with this bioinformatic tool. Participants are encouraged to bring their own notebooks to “play” with Antismash and solve some “genome mining exercises.”
11:30-11:50 coffee break & team building
Chair Maria Chiara Monti (ISSNP committee member)
11:50 – 12:40 The vision of young scientists’
Short presentation by participants
11:50 – 12:00 De Rosa Teresa
University of Naples Federico II
Identification of a New Cyanobacterial Genus in the Thermal Waters of Bagni San Filippo with Antioxidant and Anti-inflammatory Potential
12:00 – 12:10 Di Matteo Viviana
University of Naples Federico II
Unraveling Thermoactinoamides: Molecular Networking, Biosynthesis, and Unexpected Epimerization
12:10 – 12:20 Lopez-Mobilia Andrea
Stazione Zoologica Anthon Dohrn
Exploring the Antimicrobial Potential of Coral-Associated Bacteria using the OSMAC Approach
12:20 – 12:30 Raucci Carlo
University of Campania Luigi Vanvitelli
Nematicidal agents from endophitic fungus Trichoderma parceramosum
12:30 – 12:40 Scognamiglio Paolo
University of Naples Federico II
Systematic Valorization of Brewing Trub via LC–HRMS/MS and Feature-Based Molecular Networking
12:40-13:00 Q&A
13:00 -14.00 Lunch
15:00-16:30 PHOTO TALENT SCOUTING
Photography in Research by Salvatore Esposito, Valeria Costantino, Giorgia Oliviero, Luigi Milella, Germana Esposito, Roberta Teta.
Photography techniques applied to the communication of results
Session II: Bioinformatic and NPs
Gain insights into the bioinformatic approach that revolutionized the dereplication process.
Lectures
16:30–17:00 Jean-Luc Wolfender
School of Pharmaceutical Sciences, University of Geneva (Switzerland)
Title: Is AI ready to take NP research to the next level?
17:00-17:30 Daniel Petras
Department of Biochemistry, University of California, Riverside (USA)
Title: Functional Metabolomics Approaches for Natural Product Discovery
17:30-18:00 Q&A
19:00-20:00 Join the ISSNP Community by the Pool- Networking Aperitif
20:30 Dinner & WORKING @Team Building Activity (PHOTO CONTEST) with Salvatore Esposito
1st July
Tuesday
Session III: From Theory to Practice: Applications of Molecular Docking in Natural Products Drug Discovery
Lecture
9:00 – 9:30 Nikolay T. Tzvetkov
Institutions: Institute of Molecular Biology, Bulgarian Academy of Sciences (IMB-BAS), Sofia (Bulgaria)
Title: Molecular docking as a key tool in drug development: let’s make it understandable
Workshop
9:30 –11:30 Maria Ponticelli
Department of Health Science, University of Basilicata, Potenza (ITALY)
Explore the powerful molecular docking tool and understand the mechanisms governing ligand-receptor interactions. Learn about interactive preparation and visualizazion of protein-ligand complexes and generate MedChem structure-activity hypothesis. The first part of the session will introduce the basic principles and concepts underlying molecular docking as a fascinating technique for discovering and designing novel drugs. The second practical part will show how to easily dock and score molecules within the protein-ligand complexes using free-accessible web tools. Specifically, a comprehensive exploration of the intricate world of molecular docking and step-by-step docking procedures will be performed. Through engaging visuals and interactive content, participants will learn about the essentials needed to conduct basic molecular docking studies. Bring your own laptop, ensure your free Internet access, and play along during the workshop – and continue to learn back home.
11:30-11:50 coffee break & team building
Chair: Alberto Minassi (ISSNP Committee Member)
11:50 – 12:45 The vision of young scientists’
Short presentation by participants
11:50 – 11:55 Ayinde Mercy Ebunoluwa
University of Campania Luigi Vanvitelli
Anti-Candida Activities of Andrographis paniculata and Structural Elucidation of Ent-Labdane Diterpenes
11:55 – 12:00 Barbato Rosa
University of Naples Federico II
Investigating the Role of Bile Acid−Amino Acid Conjugates in Human Cholestatic Diseases
12:00 – 12:05 Corretto Daniele
University of Naples Federico II
Metabolomic profiling of Cynara cardunculus as a source of nutraceuticals against kidney and liver diseases
12:05 – 12:10 di Biase Edoardo
University of Piemonte Orientale
Mimicking Nature in reshaping the triterpene skeleton: synthesis of a new class of unnatural oleane
12:10 – 12:15 Monticelli Luca
University of Naples Federico II
Metabolomic Profiling of Extracts from Helichrysum stoechas and Their Potential Pharmacological Activities for Therapeutic Applications
12:15 – 12:20 Fusto Letizia Maria
University of Catania
Sustainable Extraction and Chemical Transformation of Anthocyanins into Pyrano-anthocyanins for Textile Purposes
12:20 – 12:25 Tuseef Muhammad
University of Basilicata
Optimization of Bioactive Compounds Extraction from Common Bean (Phaseolus vulgaris L.) Pods Using Response Surface Methodology
12:25 – 12:35 Fossati Alice
University of Pavia
Identification of Natural Products with Potential Against Tyrosinase-Linked Disorders
12:35 – 12:45 Mangieri Claudia
University of Basilicata
From Orchard to Follicle: Annurca Apple as a New Frontier in Preventing Hair Loss
12:45-13:00 Q&A
13:00 -14.00 Lunch
Session IV: From Nature to Our Cells: The Incredible Journey of Natural Substances
Lecture
15:00-15:30: Nicola Borbone
Department of Pharmacy, University of Naples ‘Federico II’ (ITALY)
Title: Non-canonical structures of DNA
Workshop
15:30-15:50 Francesca Ghirga
Department of Medicinal Chemistry and Technology, University of Rome ‘Sapienza’, Rome (ITALY)
Title: Building Natural Product-Based Libraries for Drug Discovery: Challenges and Opportunities
15:50-16:10: Alessio Bartocci
University of Milan, Milan (ITALY)
Title: From Theory to Practice: Application of Molecular Docking in Nucleic acid
16:10-17:00: Molecular docking interactive session (Francesca Ghirga and Alessio Bartocci)
Chair: Vera Muccilli (ISSNP Committee Member)
17:00 – 18:00 The vision of young scientists’
Short presentation by participants
17:00 – 17:10 Biancucci Cristiano
University of Rome Sapienza
Identification of Natural Compounds as G-Quadruplex Stabilizers for the Development of New Antimicrobial Agents
17:10 – 17:20 Boccia Eleonora
University of Salerno
Unraveling the stereochemical complexity of novel 18-membered macrolides from Nocardia brasiliensis: an integrated QM/NMR approach
17:20 – 17:30 Bossoni Aurora
University of Piemonte Orientale
Synthesis of Abnormal Cannabinoids: writing a novel chapter in the Cannabinoid Encyclopedia
17:30 – 17:40 Pozzi Luca
University of Milan
New SARS-CoV-2 bivalent inhibitors: Natural products as building blocks
17:40 – 17:50 Prado Romero Diana Lorena
University of Trieste
Potential bioactivity of natural products from coffee seeds with a structure-based approach
17:50 – 18:00 Stornaiuolo Alessia
University of Naples Federico II
Novel molecular insight into the interaction of Siglec-8 with sialylated ligands
18:00-18:15 Q&A
18:30 Join the ISSNP Community by the Pool
20.30 Dinner & WORKING @ Team Building activity (PHOTO CONTEST)
2nd July
Wednesday
09:00-13:00 Vesuvio or Ercolano Tour
13:00 Lunch
Workshop
15:00 –17:00 Roberta Teta, Germana Esposito, Paolo Stincone and Daniela Herrera-Rosero
Department of Pharmacy, University of Naples ‘Federico II’ (ITALY)
University of Tuebingen (GERMANY)
Title: Unlocking Mass Spectrometry Data: Molecular Networking and Bioinformatic Analysis with GNPS
The workshop will provide participants the tools to process and analyze mass spectrometry data, build molecular networks, and interpret the resulting visualizations. Participants will gain hands-on experience with bioinformatic platforms like GNPS (Global Natural Products Social Networking), learning how to prepare, upload, and analyze their data. The practical session will allow attendees to explore real-world datasets and construct molecular networks to identify potential metabolites. Participants are encouraged to bring their laptops to engage with the tools actively.
17:00-18:00 William Gerwick (online, ISSNP External Board Member)
Scripps Institution of Oceanography, University of California, San Diego (USA)
Title: Application of Artificial Intelligence to Aid in the NMR-Based Structure Determination of Natural Products
Society has rapidly adopted artificial intelligence in many aspects of everyday life. This presentation will describe the use of two publicly available AI tools, SMART 2.0 and DeepSAT, that allow insights into the structural features of new natural products from their 1H-13C HSQC data. After a brief explanation of the underlying principles, students will evaluate these two tools themselves with test set data as well as their own datasets. Participants are encouraged to bring their own notebooks or laptops to “play” with these two tools.
Chair: Valerio Fasano (ISSNP Committee Member)
18:00-18:30 The vision of young scientists’
Short presentation by participants
18:00 – 18:05 Cafora Raffaele
University of Naples Federico II
Study of Bagni San Filippo Thermal Springs (SI): Detection of Cyanobacteria and Assessment of Cytotoxic Activity in Environmental Extracts
18:05 – 18:10 Cammarota Mattia
University of Naples Federico II
Clonostachys rosea: a source of peptaboils with antiviral and antimicrobial properties
18:10 – 18:15 Moretti Eleonora
Stazione Zoologica Anton Dohrn
Natural products from mangroves associated microorganisms: a promising frontier
18:15 – 18:20 Quaini Giulia
Institute of Biomolecular Chemistry (CNR-ICB)
Chemistry signaling of the eco-physiological mechanisms in marine opisthobranchs
18:20 – 18:25 Sciarra Beatrice
University of Rome Sapienza
Identification of Natural Chemotypes as KPC-3 Carbapenemase Inhibitors
18:25 – 18:30 Varola Giulia
Stazione Zoologica Anton Dohrn
Ultraviolet-protective properties of a coral-associated bacterium Pseudoalteromonas sp.
20.30 Dinner & WORKING @ Team Building activity (PHOTO CONTEST): Photo editing
3rd July
Thursday
Session VI: PROTEOMICS
Lecture
09:30–10:00 Maria Chiara Monti
Department of Pharmacy, University of Naples ‘Federico II’, (ITALY)
Title: A Multidisciplinary Approach for Natural Products Target Deconvolution Based on Functional Proteomics.
Workshop
10:00–11:30 Elva Morretta
Department of Pharmacy, University of Naples ‘Federico II’, (ITALY)
The main focus is to learn how the discovery of natural product targets has been boosted by functional proteomics in recent years. The workshop’s first section will utilize Proteome Discoverer to identify protein targets of natural products using real data. In contrast, the second section will provide tools for the gene ontology analysis of the identified protein targets. Participants can familiarize themselves with various bioinformatic tools through these hands-on sections. It is recommended that participants bring their own notebooks so they can “play” with web-free apps such as String, David, and Proteome Dis-coverer.
13:00 -14.00 Lunch
15:00 -16:00 Team building activities’ presentations
16:00-17:00 Awards Ceremony
ISSNP Awards:
Team Building Activity Best Team
Best Oral
18:00 Closing remarks and PARTY: just having fun together!